Cassava is the 4th most consumed root crop that contributes to dietary energy in the tropics (after rice, sugar, and maize). Thus, cassava continues to be recommended as a key food for human consumption, especially in the face of current population growth, related problems with food supply, food and nutrition security, and global climate change challenges. Research on cassava crops aims to improve agricultural resource management, and breeding. Along with seed production, crop protection, post-harvest practices, storage, supply chain, potential uses, and food security. There has also been significant technological advances in cassava production systems that have remarkably improved cassava yields and the technological processing of derivatives. However, these developments are still poorly understood throughout the world. This book, therefore, aims to provide an overview of the current state of sustainable cassava production systems, improve processing and potential uses, to achieve global food security targets by presenting research, case studies, experiences, opinions, and critical comments from various agroecological regions of the world.