SYSTEMS SCIENCE AND POPULATION HEALTH employs principles from across a range of sciences to refine the way we understand population health. By augmenting traditional analytic approaches with new tools like machine learning, microsimulation, and social network analysis, population health can be studied as a dynamic and complex system. This allows us to understand population health as a complex whole, offering new insights and perspectives that stand to improve thehealth of the public. This text offers the first educational and practical guide to this forward-thinking approach.