Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serials tradition of providing an insight into the skills required of the modern medicinal chemist in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.