Written for DNP and PhD nursing programs, this text, based on a unique team-taught philosophy of science nursing course, distills challenging content and delivers it in clear, highly accessible language for professors untrained in philosophy and their students. Authored by a nurse researcher/philosopher team who developed and taught this course for over seven years, the book provides a unique integrated viewpoint that avoids esoteric and overly theoretical discussions and facilitates a clear connection of the philosophy of science with nursing science and practice. This second edition has been revised to enhance modern philosophy of science interpretation, enhance overall clarity, encompass updates in nursing practice, science, and embrace a still emerging practice epistemology. It is distinguished by its increased emphasis on DNP investigation that relies on a fundamental relationship with evidence-based practice.