Twelve Brain Principles That Make the Difference, by Brian Pete and Robin Fogarty, is about how the brain learns best and all the things teachers can do to facilitate the learning part of the teaching scene. This book presents a unique organization of Renate and Geoffrey Caines twelve brain principles. The twelve principles are arranged in four specific quadrants. Each quadrant speaks to a particular aspect of the high-achieving classroom and highlights how instructional decisions are governed by the twelve principles.