Working in the ever-evolving field of smart chip design within an AI-powered design environment, the authors of this book draw on their experiences in successfully developing system-on-chip (SoC) solutions, having grappled with the emerging design environment, innovative tools, domain-specific challenges, and major design decisions for SOC-based solutions. They present the first comprehensive guide to navigating the technical challenges of SOC-based solutions in emerging application domains, covering various design and development methodologies for system-on-chip solutions for emerging target applications. When diligently applied, the strategies and tactics presented can significantly shorten development timelines, help avoid common pitfalls, and improve the odds of success, especially in AI-powered smart EDA environments. The book provides a detailed insight into SoC-based solutions for various applications, including artificial intelligence (AI), post-quantum security feature enhancements, 3D SOCs, quantum SOCs, photonic SOCs, and SOC solutions for IoT, high-performance computing SOCs, and processor-based systems. The coverage includes architecture exploration methods for targeted applications, compute-intensive SoCs, lightweight SoCs for IOT applications, advanced technology node solutions, and solutions including hardware software co-designs and software-defined SoCs. The strategies best applied in these highly advanced technology developments are discussed in a guest chapter by a practicing high technology strategist so innovators, designers, entrepreneurs, product managers, investors, and executives may properly prepare their companies to succeed.