London: December 1888. The notorious and as-yet undiscovered genius, Vincent van Gogh, presents Sherlock Holmes with a most unusual case. Aided by his partner Dr. Watson and his paramour Irene Adler, the trio embark on a rousing adventure and find themselves confronting the evil daughter of Professor Moriarty. With a helping hand from Oscar Wilde, the world's greatest detective attempts to solve one of the most audacious crimes of the Victorian era and uncover a Post-Impressionist conspiracy.