This issue of Veterinary Clinics: Exotic Animal Practice, guest edited by Dr. Vladimír Jekl, is dedicated to Respiratory Medicine. This issue is one of three selected each year by the series consulting editor, Dr. Jörg Mayer. Topics discussed in this issue include—but are not limited to—Respiratory Tract Disorders in Fishes, Computed tomography and MRI of the respiratory tract of the reptile and avian patient, Snake Pulmonology, Respiratory disorders in chelonians, Respiratory Diseases in Parrots, Respiratory disorders in Back-yard Poultry, Respiratory Disorders in Guinea pigs, Chinchillas and Degus, Respiratory Disorders in Rabbits, Diagnostics of infectious respiratory pathogens in reptiles, and Respiratory Disorders in Ferrets.