Neutron Activation Analysis (NAA) is the most common technique used in research reactors worldwide. The IAEA aims to enhance quality assurance in NAA laboratories by supporting annual proficiency testing, by developing and offering relevant e-learning as well as specialized publications. This publication, which is based on the most up to date relevant ISO guides and international practices, provides practical guidance on quality assurance (QA) and quality control (QC) in NAA laboratories. It is intended to be used in the day-to-day work of NAA at research reactors. Potential sources of errors and associated QA/QC actions are detailed for all main areas of NAA practice. Easy to use tables are provided, intended for direct reference in the laboratory.