This book offers an extensive and comprehensive description of platelet concentrates in the field of periodontal regeneration as well as a more specific description of biological properties and biologic efficacy of these concentrates. The evolution of platelet concentrates and their application in periodontal therapy as well as their limitations are explained. The book also details treatment protocols and methods with demonstrated success. The development of bioactive surgical additives to regulate inflammation and increase the speed of the healing process is one of the great challenges in clinical research. Platelet concentrate has a higher number of platelets per millimeter and, therefore, contains a higher concentration of growth factors to enhance regeneration. Platelet-rich plasma (PRP) is the first generation of platelet concentrate. However, the short duration of cytokine release and its poor mechanical properties have resulted in a search for new material. Platelet rich fibrin (PRF) appears as a natural and satisfactory alternative with favorable results and low risks. This monograph may prove extremely useful for clinicians and those pursuing undergraduate and postgraduate education in the fields of dentistry and medicine. The information compiled in this monograph will continue to provide interesting and new information for teachers and faculty members in the field of dentistry. This review will surely give valuable information for achieving the highest standard in clinical dentistry.