In this issue of Critical Care Clinics, guest editors Drs. Yahya Shehabi, Joanna L. Stollings, and Timothy D. Gerard bring their considerable expertise to the topic of Optimizing Sedation and Analgesia in the ICU. Top experts cover key issues such as the role of antipsychotic agents for adjunct sedation; analgesia first for every patient: current concepts in critical illness; monitoring sedation depth in critical illness; inhalational agents as ICU sedatives; and much more. - Contains 14 relevant, practice-oriented topics including optimal sedation in the elderly critically ill; sedation in non-invasive ventilation; optimal sedation in ventilated patients with septic shock; optimal sedation in the patients with acute brain injury including post cardiac arrest; future directions in sedation and analgesia; and more- Provides in-depth clinical reviews on optimizing sedation and analgesia in the ICU, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews