This book is a curated compendium, uniting insightful contributions from the realms of psychiatry, psychotherapy, and psychopharmacology. Its primary focus is a detailed exploration of mental pain - a conceptual terrain often underexplored, yet profoundly impactful on the broader spectrum of mental well-being. At the outset, the book establishes mental pain as a fundamental construct, positioning it as a linchpin for an extensive and meticulous analysis of its relevance within prevalent mental health diagnoses. Diagnoses such as major depressive disorder, bipolar disorder, personality disorders, and eating disorders are closely examined, seeking to describe the ways in which mental pain intersects with these conditions. The volume discusses its implications for the domains of suicidal and self-harm risks, underscoring the imperative for a nuanced comprehension of mental pain and evidence-based interventions, crucial for both adult and adolescent populations.As the book unfolds, it navigates the complex landscape of assessment and treatment methodologies with precision and depth. Contributors bring forth a discerning analysis of therapeutic approaches, weaving together established clinical paradigms with contemporary, evidence-based strategies. This book is aimed at equipping readers with the most current insights gleaned from evidence-based literature on mental pain. The intended audience encompasses clinicians seeking to confront this pervasive issue within their clinical practice and researchers driven to expand their understanding of the current knowledge.