Judah ben Joseph Moscato (c.1533-1590) was one of the most distinguished rabbis, authors, and preachers of the Italian-Jewish Renaissance. The book Sefer Nefusot Yehudah belongs to the very centre of his important homiletic and philosophical oeuvre. Composed in Mantua and published in Venice in 1589, the collection of 52 sermons addresses the subject of the Jewish festivals, focussing on philosophy, mysticism, sciences and rites. This and subsequent volumes will provide a critical edition of the original Hebrew text, accompanied by an English translation.