Patient safety and quality of care are critical concerns of healthcare consumers, payers, providers, organizations, health systems, and governments. Evidence shows that high reliability methods enable the most efficient, safe, and effective care; however, these methods are not the standard in all healthcare systems. Nurses-who are on the front line of providing safe and effective care-are ideally situated to drive high reliability. High Reliability Organizations: A Healthcare Handbook for Patient Safety & Quality, Third Edition, equips nurses and healthcare professionals with the tools necessary to establish an error detection and prevention system. In this new edition, authors Cynthia A. Oster and Jane S. Braaten build on the foundation of previous editions with best practices, relevant exemplars, and important discussions about cultural aspects essential to sustainability solidifying process improvements and highlighting the contributing factors that lead to enhanced outcomes.