The Induction of genotoxic effects on prokaryote and eukaryotes’ genetic materials is a crucial step in the initiation of cancer and genotoxic disease syndromes. Cancer risk assessment and other genetic disease syndromes required the application of genotoxicity biomarkers. Several genotoxicity assays have been developed and applied to assess the potentials for xenobiotics to induce DNA damage. In the edited book: "Genotoxicity: Advances in Research and Applications", the applications of genotoxicity biomarkers were used to monitor heat-induced genotoxic agents in the reproductive system. Genotoxicity assays were applied in the assessment of genomic instability induced by environmental xenobiotics (including cement dust and pesticides) that humans and biota are exposed to in occupational settings and the environment. Advances in the application of genotoxicity include the use of in silico techniques to predict the genotoxic potentials of xenobiotics including pharmaceuticals which are increasingly being accumulated in the environment. Renounced authors in the field of genotoxicity have made comprehensive contributions to achieve the quality of the book contents.