This book includes six chapters that detail the consumption, benefits, and effects of fish oil. Chapter One discusses the impact of long-chain n-3 PUFA on changes in the inflammatory and chemotactic paracrine interactions between various immune cell populations (macrophages and T cell subsets) and adipocytes that contribute to obese adipose tissue dysfunction. Chapter Two summarizes the current literature on the role of epigenetic modifications on the association between fish oil consumption and reproduction performance. Chapter Three provides a comprehensive update on chemopreventive and chemotherapeutic efficacy of fish oil alone or in combination with standard drugs against colorectal cancer development and progression. Chapter Four discusses the development of various cell culture models to recapitulate obesity-associated adipocyte-immune cell paracrine interactions utilizing mature 3T3-L1 adipocytes or conditioned media from primary adipose tissue explants co-cultured with either purified primary immune cell populations or immune cell lines. Lastly, Chapter Five focuses on the significance and impact of dietary lipids on the growth, maturation, reproductive performance, and other aspects viz, immunity, fatty acid profile and lipid level requirements in diets of carps and their variants.