In this issue of Clinics in Perinatology, guest editors Drs. Asaad Beshish and Holly Bauser-Heaton bring their considerable expertise to the topic of Epidemiology and Genetics of Congenital Heart Disease. Adult survivors of CHD commonly experience cardiac and non-cardiac comorbidities which affect quality of life and prognosis. Genetic etiologies of CHD have important clinical implications for genetic counseling of patients and families and can affect clinical outcomes by identifying at-risk patients. This issue highlights the epidemiology and genetic components of heart defects with an eye on future outcomes and quality of life. - Contains 12 practice-oriented topics, including PDA closure in preterm, IUGR infants, and patients with chronic lung disease of prematurity; cardiology overview of pulmonary hypertension management in the neonatal intensive care unit; atrial tachycardia in the neonate; long-term outcomes of congenital heart disease; and more- Provides in-depth clinical reviews of epidemiology and genetics of congenital heart disease, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews