In this issue of Pediatric Clinics of North America, guest editor Dr. Michael R. DeBaun brings his considerable expertise to the topic of A Primer for Pediatric Clinicians: Management of Acute and Ongoing Sickle Cell Disease. As the responsibility for primary and secondary care of children with SCD is increasingly being shifted to general pediatricians, this issue has been developed to support pediatric clinicians in this role. Top experts provide essential pediatric care principles and management strategies for integrating SCD care into the routine practice of a busy pediatric clinician's office, ensuring that children with SCD receive the comprehensive care they need in a medical home setting. - Contains 15 relevant, practice-oriented topics, including newborn screening for SCD in the U.S.: gaps in medical care; assessment of school readiness for children with SCD; approach to benefits and limitations of exercise in children with SCD and sickle cell trait; in-office screening for anxiety, depression, and suicide ideation in children and adolescents with SCD; referring children and adolescents with SCD for curative therapy; and more- Provides in-depth clinical reviews on management of acute and ongoing sickle cell disease, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews