In this issue of Critical Care Clinics, guest editors Drs. Sarah M. Perman, Robert A. Berg, and Vinay M. Nadkarni bring their considerable expertise to the topic of Cardiac Arrest and Cardiopulmonary Resuscitation. Top experts cover key issues such as physiology-guided CPR; emerging biotechnology: mitochondria, genomics, personalized medicine; implementation challenges in emergency cardiovascular care; a state-of-the-art update in E-CPR; defibrillation strategies; and much more. - Contains 14 relevant, practice-oriented topics including assisted ventilation during CPR; cardiac arrest pharmacopeia; ethics/organ donation; resuscitation of LVAD cardiac arrest; multi-modal neuro-prognostication; overdose-associated cardiac arrest in the era of the opioid epidemic; and more- Provides in-depth clinical reviews on cardiac arrest and cardiopulmonary resuscitation, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews