The book brings together the contributions of the 8th International Conference on Smart Learning Ecosystems and Regional Development aimed at promoting reflection and discussion on the relevance of smart learning ecosystems for regional development and social innovation (e.g., schools, campuses, working places, informal learning contexts) and on how the effectiveness of the relation of citizens and smart ecosystems can be boosted. This forum is interested in understanding how technology-mediated instruments can foster the citizen’s engagement with learning ecosystems and territories, namely by understanding innovative human-centric design and development models/techniques, education/training practices, informal social learning, innovative citizen-driven policies, technology-mediated experiences, and their impact. This set of concerns contributes to fostering the social innovation sectors and ICT, economic development, and deployment strategies alongside new policies for smarter proactive citizens.