Ribosome Biophysics

In the proposed book, the goal will be to present a range of examples for how the adoption of physical-chemical/statistical-mechanical concepts and techniques has allowed for precise physical insights to be obtained for the ribosome. While the text will focus on the ribosome, it is the editors expectation that this could serve as an introduction for physics-trained scientists (bachelors and higher) as they move into the study of other biological assemblies. To this end, the plan is to collect contributions from leaders in the field who have used physically grounded approaches to address this complex biomolecular assembly. This will include discussions of all aspects of ribosome function (assembly, catalysis, protein synthesis and machine-like dynamics). By covering this broad range of processes, the reader will be introduced to physical principles that guide dynamics in the ribosome.

In the proposed text, contributions from leading researchers will be invited, where the physical principles and questions will be described, as well as the current state of our understanding. In particular, the authors will focus how to characterize the energetics of a range of biologically relevant processes in the ribosome.

Key Feautres:

• Presents a range of examples for how the adoption of physical-chemical/statistical-mechanical concepts and techniques has allowed for precise physical insights to be obtained for the ribosome
• It will serve as an introduction for physics-trained scientists (bachelors and higher) as they move into the study of other biological assemblies
• Discussions will include all aspects of ribosome function (assembly, catalysis, protein synthesis and machine-like dynamics)
• Readers will be introduced to the physical principles that guide dynamics in the ribosome, as well as theoretical and experimental techniques that are suitable for further study.
• Proposed chapter authors (including two Nobel Laureates) are world class researchers in their respective fields.