The Quality Management Audits in Nuclear Medicine (QUANUM) programme has proven to be applicable to many nuclear medicine services across a variety of economic circumstances. It considers the diversity of nuclear medicine practices around the world and covers multidisciplinary contributions. The present revision, QUANUM 3.0, follows the principle of continuous quality improvement and reflects new scientific developments. It draws on valuable lessons learned from more than a decade of global implementation of QUANUM with the assistance of experienced nuclear medicine professionals.